In parallel, T-cell activation slightly increased between D14 and D45 while PD-1+ CD4 and CD8 T cells declined at D30 ( Figure 1B and C). ![]() The plasma HIV load progressively and modestly increased up to 101 copies/ml at D45, decreasing afterwards to 31 copies/ml at D120. Fifteen injections were administered every 14 days until July 2017, with a stable disease, and a good tolerance with stable CD4 and CD8 counts despite a slight CD4 drop at D30 ( Figure 1A). Pre-treatment plasma HIV load was undetectable (<20 copies/ml) under emtricitabin, tenofovir and dolutegravir started in August 2016. CANCERVIH is a national French multidisciplinary network dedicated to HIV-infected patients with cancer. Relapse occurred <6 months after the end of chemotherapy and nivolumab was introduced as a second line in December 2016, upon the CANCERVIH working group recommandations. ![]() A 51-year-old man, smoker, HIV-infected since 1995, diagnosed with stage IIIa epidermal growth factor receptor-/ BRAF-/ Kras-/Programmed Cell Death Ligand-1- non-small-cell lung cancer in May 2015 was treated with lobectomy and adjuvant chemotherapy (cisplatin and pemetrexed).
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